ABSTRACT
Background: Context: Complains of pain in throat have been recorded in patients subjected to intubation of the trachea to such an extent as requiring analgesic interventions.In the modern multi-modal analgesia approach, non-opioid and NSAID group of drugs are in vogue to provide perioperative analgesia. Ketorolac and Paracetamol are two such drugs employed to treat surgical pain. Aim: To study and compare the effectivity of Ketorolac and Paracetamol in decreasing throat pain following endotracheal intubation. Settings and design: Prospective randomised parallel assigned single blind control study. Methods: Conducted on 120 consenting adult patients who required endotracheal intubation for surgery.They were divided into 3 groups of 40 patients each - C, K and P.Group K patients were premedicated with IV Inj.Ketorolac and Group P patients with IV Inj.Paracetamol 10minutes before induction of anaesthesia.Group C patients were the Control group.All patients were administered standard identical general anaesthetics .After recovery from anaesthesia, the incidences and severity of pain in throat was assessed and graded.The observations were tabulated and statistically analysed. Statistical analysis used: OpenEpi online software. Results: Both Ketorolac and Paracetamol decreased incidences and severity of throat pain. Ketorolac premedication provided better results than Paracetamol. Conclusion: Intravenous Ketorolac and Paracetamol both lessen sore throat caused by tracheal intubation.
ABSTRACT
Background: Both Propofol and Sevoflurane have been seen to decrease the haemodynamic stress response obtained with oro-tracheal instrumentation. But they are also associated with significant depression of cardiovascular system. With the aim to gain benefit from both these agents but lessen the cardiovascular depressive manifestations, we induced the patients using both the agents in decreased dosages and observed the effects there upon on haemodynamic parameters. Methods: 30 patients were given to inhale Sevoflurane(4%) in Oxygen and were also administered intravenous Propofol (1mg/kg) for induction of general anaesthesia. Aided by IV SuccinylCholine(1mg/kg), trachea was intubated under direct laryngoscopy. Results: The Systolic , Diastolic, Mean Blood Pressure values and Pulse rates were noted before and after induction and following intubation and the observations were analysed. Conclusion: .Anaesthesia induction with Propofol and Sevoflurane combination blunts the haemodynamic stress response.